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KMID : 0371320070730030204
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Journal of the Korean Surgical Society
2007 Volume.73 No. 3 p.204 ~ p.209
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Expression of Topoisomerase II α and Ki-67 in Invasive Mammary Carcinoma and Their Clinicopathologic Implication
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Oh Sang-Min
Kim Dae-Cheol
Joh Se-Heon
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Abstract
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Purpose: Various prognostic indicators have been identified for mammary carcinomas, but the issue of their significance remains unsettled. The prognostic impact of c-erb B2, Ki-67 and topoisomerase II α expression was investigated in relation to prognostic factors for carcinomas of the breast and to the tumor cell growth fraction.
Methods: One hundred eighteen cases of invasive mammary carcinoma were investigated by immunohistochemical staining for c-erb B2, topoisomerase II α, and Ki-67. Clinicopathologic parameters were compared with the expression pattern and incidence of c-erb B2, topoisomerase II α and Ki- 67 in invasive mammary carcinoma.
Results:C-erb B2 showed significant correlation with topoisomerase II α (P＜0.05), but others were not significant. Topoisomerase II α and Ki-67 index closely paralleled each other, indicating that both reflect the proliferate activity of tumor cells and were associated with high nuclear and histological grade, ER and PR expression (P＜0.05).
Conclusion:These results indicate that ki-67 and topoisomerase II α proteins might play a role in tumor progression of breast carcinoma. The Ki-67 and topoisomerase II α index may be proliferate factors of breast cancer. In addition, the increase expression of Ki-67 and topoisomerase II α and hormone receptor were closely correlated each other, and could be used as factors suggesting poor prognosis in breast carcinoma.
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KEYWORD
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Breast cancer, c-erb B2, Topoisomerase IIα, Ki-67
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